Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans.[T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection.[T716] The caffeine citrate injection, used for apnea of the premature newborn, was initially approved by the FDA in 1999.[L9863] According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. Premature birth can lead to apnea and bronchopulmonary dysplasia, a condition that interferes with lung development and may eventually cause asthma or early onset emphysema in those born prematurely.[A187694] Caffeine is beneficial in preventing and treating apnea and bronchopulmonary dysplasia in newborns, improving the quality of life of premature infants.[T716]
Synonyms
Caféine
Coffein
Methyltheobromine
Caffeine citrate
Coffeinum
Guaranine
Teína
3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
7-methyltheophylline
Caffeine
Mateína
1,3,7-trimethyl-2,6-dioxopurine
Koffein
1-methyltheobromine
Cafeína
Thein
1,3,7-trimethylpurine-2,6-dione
Theine
1,3,7-trimethylxanthine
Caffeinum
Anhydrous caffeine
Brand Names
PANADOL Extra
Pain Away Plus
Butalbital, Aspirin, Caffeine, and Codeine Phosphate
BioElectro Day
Menstrual Complete Pain Relief
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate
Best Choice Pain Relief Powder
Gel
Added Strength Pain Reliever
Tension Headache Relief Aspirin Free
Acetaminophen, Caffeine and Codeine Phosphate Tablets
Exaprin
Elevate Hair Regrowth Foam
Vanquish Digital Headache
Harris Teeter Migraine Relief
Adults Acetaminophen and Caffeine Pain Reliever Fever Reducer
Extra Strength Menstrual Complete
Bc
Diurex Water Pills XPL
Arthriten Inflammatory Pain Formula
Aerotab Pain Reliever
Tension Headache Relief
Painex Tab 0.5gr
PhysiciansCare Extra Stregth Pain Reliever
Alertness Aid Stay Awake
Excedrin Migraine, CVP HEALTH
7 Select Migraine Formula
Butalbital, aspirin, and caffeine
Good Sense headache formula added strength
Acetaminophen Aspirin Caffeine
Unishield Pain Ache
Powerbooster Mild
Powerbooster original
Tylenol With Codeine No. 3 - Tab
A & C Tablets With Codeine 15mg
Acetaminophen 500 Mg With 15 Mg Caffeine and 8 Mg Codeine Phosphate
Extra Pain Relief Acetaminophen, Aspirin (NSAID) and Caffeine
A.C. & C. 8mg
Extra Strength Tylenol Total Cough, Cold & Flu
Pain Stopper Extra
Cafergot
Headache Relief Mild
Pain Stoppers
Exdol-15
SMITH BROS WILD CHERRY DAY TIME with Caffeine Soothing Drops
Extra Strength Midol Relief
Cafcit
Stay Alert Aid
292 Tablets
Goodys Extra Strength
Ergotamine
MigraTen
Norgesic Tab
Orphengesic Forte
Equaline migraine formula
Circle K Headache Relief Extra Strength
C2 Buffered With Codeine Tab
Extra Strength Pain Reliever
Tylenol No 1 Tab
Triatec-8 Fort
Ache and Pain Relief to Go
Triatec-8
Butalbital, Acetaminophen, and Caffeine
A.C. & C. 8 mg
Health Mart Stay Awake
Extra Pain Reliever
Allertness Aid
Norgesic Forte
C T Acetylsalicylic Acid Codeine and Caf Tab
Acet 3
Excedrin Tension Headache Pain Reliever
Ana-dent
Back and Body Extra Strength
Exdol 8 Tab
Pain Free
Good Sense Headache Relief
Extra Strength Tylenol Daytime Relief
Tension Headache
Sunmark Migraine Relief
Fiorinal with Codeine
Medi First Pain Relief
Acetylsalicylic Acid, Caffeine and 8 Mg Codeine Phosphate
Thrulife Extra Strength Headache Relief
Acetaminophen 500mg and Caffeine 65mg
Teva-tecnal C 1/2
Indication
Caffeine is indicated for the short term treatment of apnea of prematurity in infants and off label for the prevention and treatment of bronchopulmonary dysplasia caused by premature birth.[T716,L9851] In addition, it is indicated in combination with sodium benzoate to treat respiratory depression resulting from an overdose with CNS depressant drugs.[L9899] Caffeine has a broad range of over the counter uses, and is found in energy supplements, athletic enhancement products, pain relief products, as well as cosmetic products.[T716,L9854,L9872]
Categories
Alkaloids
Anorexigenic Agents & Respiratory and CNS Stimulants
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682