SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

Find Related PDB Entry
112 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 228,135 entries where SER is found in a polymer sequence

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133
Name	Serine
Groups	investigational nutraceutical
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	L-Serine Serine Ser Serinum Serina alpha-Amino-beta-hydroxypropionic acid (S)-2-Amino-3-hydroxypropanoic acid (S)-Serine beta-Hydroxyalanine
Brand Names	Renamin (amino Acids) Injection RenAmin Aminosyn II 8.5% Injection Aminosyn II 7% With 10% Dextrose Aminosyn-PF 10% Travasol Aminosyn II with Electrolytes Vamin 18 Electrolyte-free Aminosyn 5% Olimel 4.4% E 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II HepatAmine 8.5% Freamine III Clinisol FreAmine HBC Clinimix E Aminosyn II 10% With Electrolytes Aminosyn-PF 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Premasol - sulfite-free (Amino Acid) ProSol Smofkabiven Peripheral Vamin N Olimel 5.7% E Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn 8.5% Aminosyn II 5% Inj Aminosyn Sulfite Free Olimel 7.6% E Plenamine FreAmine III Aminosyn 10% W Electrolytes Aminosyn II and Dextrose 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Clinimix 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II in Dextrose Aminosyn HF 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Smofkabiven Extra Nitrogen 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn-PF 7% Periolimel 2.5% E Aminosyn II 7% Injection 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Smofkabiven Olimel 4.4% Olimel 7.6% ProcalAmine Aminosyn Primene Aminosyn II 7% M In 10% Dextrose(dual Chamber) Novamine 20% Prosol Aminosyn 8.5% Injection With Electrolytes Aminosyn II 8.5% With 50% Dextrose Aminosyn II In Dextrose Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Olimel 5.7% Hepatasol Primene 10% Primene 10%-liq IV Nutrineal Pd4 Perikabiven 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn 7% TrophAmine Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II with Electrolytes in Dextrose with Calcium Kabiven Aminosyn II 7% With 50% Dextrose Aminosyn 3.5% M Olimel 3.3% E Synthamin Essepna Smofkabiven Electrolyte Free
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:33384, CHEBI:17115
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01