SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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119 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 232,443 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	Serine Serina (S)-2-Amino-3-hydroxypropanoic acid alpha-Amino-beta-hydroxypropionic acid (S)-Serine beta-Hydroxyalanine Serinum Ser L-Serine
Brand Names	Aminosyn II Aminosyn II and Dextrose Olimel 5.7% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II with Electrolytes in Dextrose with Calcium Clinimix E Olimel 3.3% E 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn 7% Nutrineal Pd4 Aminosyn 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Hepatasol Aminosyn-PF 10% Olimel 7.6% Aminosyn 8.5% Smofkabiven Peripheral Primene 10%-liq IV Olimel 5.7% E Travasol Aminosyn-PF 7% Aminosyn 5% Aminosyn II In Dextrose Injection Perikabiven Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn Sulfite Free 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Aminosyn II 5% Inj 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn II 8.5% With 50% Dextrose Smofkabiven Extra Nitrogen Aminosyn HF Kabiven 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinisol ProcalAmine Aminosyn 3.5% M 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn II 8.5% Injection Aminosyn II in Dextrose Plenamine 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose FreAmine HBC Aminosyn II 7% Injection Novamine Clinimix 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Smofkabiven Electrolyte Free 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Periolimel 2.5% E Primene Aminosyn 10% W Electrolytes Olimel 7.6% E FreAmine III Premasol - sulfite-free (Amino Acid) 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 4.4% E Aminosyn-PF Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec HepatAmine Aminosyn 8.5% Injection With Electrolytes Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Olimel 4.4% Vamin N ProSol Primene 10% Aminosyn II 10% With Electrolytes Smofkabiven TrophAmine 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Synthamin Aminosyn II with Electrolytes RenAmin Aminosyn II 7% With 50% Dextrose Essepna Aminosyn II 7% With 10% Dextrose Vamin 18 Electrolyte-free 8.5% Freamine III Renamin (amino Acids) Injection Aminosyn II 7% M In 10% Dextrose(dual Chamber) 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 20% Prosol
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:17115, CHEBI:33384
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01