Annotations: 8ZUI

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, G, H A, B, C, G, H, I	Tumor necrosis factor	protein binding binding molecular function activator activity signaling receptor binding death receptor agonist activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity enzyme binding protease binding cytokine receptor binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor binding protein binding binding molecular function activator activity signaling receptor binding death receptor agonist activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity enzyme binding protease binding cytokine receptor binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding identical protein binding cytokine activity	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process cellular component disassembly positive regulation of cellular component organization regulation of cellular component organization protein-containing complex organization protein-containing complex disassembly regulation of protein-containing complex disassembly cellular component organization cellular component organization or biogenesis positive regulation of protein-containing complex disassembly response to stimulus response to chemical response to xenobiotic stimulus positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of protein localization localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane extracellular matrix organization extracellular structure organization external encapsulating structure organization cellular response to stimulus response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to chemical stimulus cellular response to retinoic acid cellular response to lipid multicellular organismal process regulation of immune effector process negative regulation of biological process cytokine production negative regulation of cellular process regulation of cytokine production regulation of immune system process regulation of multicellular organismal process cytokine production involved in immune response negative regulation of macromolecule metabolic process production of molecular mediator of immune response negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response immune response negative regulation of metabolic process negative regulation of immune effector process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process immune effector process regulation of gene expression negative regulation of production of molecular mediator of immune response negative regulation of gene expression negative regulation of immune system process negative regulation of biosynthetic process immune system process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process response to hexose response to monosaccharide response to carbohydrate response to fructose leukocyte migration defense response response to stress cell migration inflammatory response leukocyte migration involved in inflammatory response cell motility positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process miRNA transcription regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of miRNA transcription positive regulation of organelle organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle regulation of mitotic cell cycle positive regulation of cell cycle process cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division biological process involved in interspecies interaction between organisms response to other organism response to Gram-negative bacterium response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus positive regulation of interleukin-8 production interleukin-8 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production regulation of interleukin-8 production cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway signaling cell communication signal transduction cell surface receptor signaling pathway via JAK-STAT regulation of chemokine production chemokine production positive regulation of chemokine production response to transition metal nanoparticle response to gold nanoparticle cellular developmental process astrocyte differentiation cell development astrocyte activation glial cell development multicellular organism development neurogenesis astrocyte development gliogenesis cell differentiation anatomical structure development system development developmental process cell activation nervous system development central nervous system development glial cell differentiation glial cell activation neuroinflammatory response intracellular signal transduction JNK cascade intracellular signaling cassette MAPK cascade fat cell differentiation regulation of developmental process regulation of cell differentiation regulation of fat cell differentiation cellular response to toxic substance response to toxic substance cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation positive regulation of cell adhesion regulation of cell adhesion positive regulation of cell-cell adhesion heterotypic cell-cell adhesion cell adhesion cell-cell adhesion positive regulation of heterotypic cell-cell adhesion regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion inflammatory response to wounding response to wounding regulation of neurogenesis regulation of cell development regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development negative regulation of cell differentiation regulation of multicellular organismal development negative regulation of developmental process negative regulation of cell development negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of RNA metabolic process positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway immune response-activating signaling pathway positive regulation of immune response positive regulation of immune system process innate immune response-activating signaling pathway regulation of innate immune response regulation of response to stimulus defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus intracellular receptor signaling pathway positive regulation of response to stimulus endolysosomal toll-like receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress innate immune response positive regulation of innate immune response defense response to symbiont toll-like receptor 3 signaling pathway response to peptide response to cytokine response to macrophage colony-stimulating factor myeloid leukocyte activation leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation response to osmotic stress response to abiotic stimulus response to salt stress positive regulation of cell communication trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission positive regulation of synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication positive regulation of signaling negative regulation of fat cell differentiation positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction regulation of signal transduction regulation of intracellular signal transduction positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction regulation of fractalkine production fractalkine production positive regulation of fractalkine production rhythmic process circadian rhythm negative regulation of extrinsic apoptotic signaling pathway in absence of ligand signal transduction in absence of ligand negative regulation of signaling regulation of programmed cell death negative regulation of cell communication extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway in absence of ligand apoptotic process programmed cell death regulation of apoptotic signaling pathway detection of external stimulus detection of stimulus involved in sensory perception of pain system process detection of mechanical stimulus involved in sensory perception of pain nervous system process response to mechanical stimulus sensory perception of pain detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of mechanical stimulus detection of stimulus involved in sensory perception positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of cellular component organization negative regulation of protein-containing complex disassembly response to activity calcineurin-NFAT signaling cascade regulation of calcineurin-mediated signaling positive regulation of calcineurin-NFAT signaling cascade regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade positive regulation of calcineurin-mediated signaling calcium-mediated signaling calcineurin-mediated signaling multicellular organismal movement musculoskeletal movement neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction positive regulation of apoptotic signaling pathway positive regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway positive regulation of apoptotic process catabolic process positive regulation of protein metabolic process macromolecule catabolic process protein metabolic process regulation of protein metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of protein catabolic process regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality gland development animal organ development animal organ regeneration liver development regeneration hepaticobiliary system development liver regeneration bicellular tight junction assembly tight junction organization cellular component biogenesis cellular component assembly negative regulation of cell junction assembly cell junction assembly cell-cell junction assembly cell-cell junction organization regulation of bicellular tight junction assembly apical junction assembly regulation of cellular component biogenesis regulation of cell junction assembly tight junction assembly negative regulation of bicellular tight junction assembly blood microparticle formation positive regulation of developmental process anatomical structure morphogenesis regulation of blood microparticle formation anatomical structure formation involved in morphogenesis positive regulation of blood microparticle formation macrophage derived foam cell differentiation foam cell differentiation positive regulation of cell differentiation regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation regulation of action potential positive regulation of action potential action potential regulation of membrane potential negative regulation of miRNA transcription negative regulation of miRNA metabolic process regulation of amide metabolic process amyloid precursor protein catabolic process regulation of amyloid-beta formation positive regulation of amyloid-beta formation regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process amide metabolic process amyloid precursor protein metabolic process amyloid-beta formation positive regulation of amide metabolic process positive regulation of amyloid precursor protein catabolic process positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of molecular function positive regulation of protein modification process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation response to 3,3',5-triiodo-L-thyronine response to acid chemical response to nitrogen compound response to amino acid response to type II interferon cellular response to type II interferon cellular response to cytokine stimulus angiogenesis regulation of vasculature development regulation of response to wounding tube morphogenesis vascular wound healing regulation of anatomical structure morphogenesis blood vessel development wound healing blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of wound healing angiogenesis involved in wound healing negative regulation of angiogenesis negative regulation of response to wounding vasculature development circulatory system development negative regulation of vasculature development regulation of angiogenesis negative regulation of response to external stimulus regulation of wound healing negative regulation of vascular wound healing regulation of vascular wound healing cellular response to nicotine response to nicotine immunoglobulin production regulation of immunoglobulin production response to isolation stress regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction negative regulation of viral genome replication viral life cycle negative regulation of viral process regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication regulation of systemic arterial blood pressure circulatory system process regulation of blood pressure negative regulation of systemic arterial blood pressure blood circulation negative regulation of blood pressure myeloid leukocyte differentiation hemopoiesis myeloid cell differentiation osteoclast differentiation leukocyte differentiation regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response heart process negative regulation of heart rate regulation of heart contraction regulation of system process negative regulation of blood circulation negative regulation of heart contraction regulation of blood circulation heart contraction regulation of heart rate positive regulation of interleukin-18 production regulation of interleukin-18 production interleukin-18 production positive regulation of nervous system development regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of glial cell proliferation positive regulation of neurogenesis positive regulation of cell development glial cell proliferation cellular response to nitrogen compound cellular response to amyloid-beta response to amyloid-beta negative regulation of cell population proliferation endothelial cell proliferation negative regulation of endothelial cell proliferation regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation regulation of type II interferon production type II interferon production positive regulation of type II interferon production positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte adhesion to vascular endothelial cell regulation of leukocyte adhesion to vascular endothelial cell leukocyte cell-cell adhesion leukocyte adhesion to vascular endothelial cell regulation of leukocyte cell-cell adhesion leukocyte tethering or rolling cellular extravasation endothelial cell apoptotic process positive regulation of epithelial cell proliferation regulation of synoviocyte proliferation synoviocyte proliferation positive regulation of synoviocyte proliferation regulation of steroid biosynthetic process fat-soluble vitamin metabolic process steroid metabolic process regulation of lipid metabolic process lipid biosynthetic process vitamin biosynthetic process vitamin D biosynthetic process positive regulation of vitamin metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process regulation of vitamin metabolic process steroid biosynthetic process small molecule biosynthetic process positive regulation of vitamin D biosynthetic process regulation of steroid metabolic process vitamin D metabolic process regulation of vitamin D biosynthetic process vitamin metabolic process positive regulation of steroid biosynthetic process positive regulation of lipid biosynthetic process fat-soluble vitamin biosynthetic process positive regulation of steroid metabolic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process lipid metabolic process regulation of inflammatory response positive regulation of inflammatory response neutrophil activation regulation of leukocyte activation regulation of neutrophil activation regulation of cell activation positive regulation of cell activation positive regulation of leukocyte activation positive regulation of neutrophil activation granulocyte activation interleukin-6 production regulation of interleukin-6 production negative regulation of interleukin-6 production positive regulation of cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly protein-containing complex assembly positive regulation of chronic inflammatory response chronic inflammatory response regulation of chronic inflammatory response to antigenic stimulus inflammatory response to antigenic stimulus positive regulation of chronic inflammatory response to antigenic stimulus regulation of chronic inflammatory response regulation of inflammatory response to antigenic stimulus chronic inflammatory response to antigenic stimulus positive regulation of inflammatory response to antigenic stimulus positive regulation of leukocyte adhesion to arterial endothelial cell regulation of leukocyte adhesion to arterial endothelial cell leukocyte adhesion to arterial endothelial cell neuron apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process response to ionizing radiation cellular response to ionizing radiation response to radiation cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus cognition negative regulation of nervous system process regulation of myelination axon ensheathment ensheathment of neurons regulation of nervous system process myelination negative regulation of myelination lipid storage lipid localization negative regulation of lipid localization regulation of lipid storage regulation of lipid localization negative regulation of lipid storage nutrient storage necroptotic process programmed necrotic cell death necroptotic signaling pathway extrinsic apoptotic signaling pathway via death domain receptors interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process glucose metabolic process chemokine (C-X-C motif) ligand 2 production regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of JNK cascade regulation of JNK cascade macrophage activation involved in immune response cell activation involved in immune response myeloid cell activation involved in immune response leukocyte activation involved in immune response establishment of protein localization nitrogen compound transport regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion regulation of hormone secretion regulation of peptide secretion transport hormone secretion protein localization to extracellular region peptide secretion regulation of secretion by cell secretion by cell amide transport signal release regulation of transport secretion regulation of peptide transport regulation of establishment of protein localization export from cell regulation of protein transport peptide transport protein transport regulation of insulin secretion peptide hormone secretion hormone transport insulin secretion negative regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration regulation of locomotion regulation of cell migration regulation of endothelial cell migration negative regulation of cell motility blood vessel endothelial cell migration locomotion negative regulation of cell migration positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity regulation of DNA-binding transcription factor activity cellular response to acid chemical cellular response to amino acid stimulus membrane lipid metabolic process regulation of membrane lipid metabolic process positive regulation of protein localization to cell surface protein localization to cell surface regulation of protein localization to cell surface response to decreased oxygen levels response to hypoxia response to oxygen levels hexose transmembrane transport D-glucose import carbohydrate transport negative regulation of transport negative regulation of transmembrane transport negative regulation of D-glucose import regulation of D-glucose import negative regulation of D-glucose transmembrane transport transmembrane transport regulation of transmembrane transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport cytokine-mediated signaling pathway cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor positive regulation of JUN kinase activity regulation of JUN kinase activity response to L-glutamate positive regulation of podosome assembly membraneless organelle assembly regulation of podosome assembly organelle assembly podosome assembly regulation of organelle assembly positive regulation of organelle assembly response to nutrient levels negative regulation of catabolic process lipid catabolic process regulation of lipid catabolic process negative regulation of lipid metabolic process negative regulation of lipid catabolic process negative regulation of branching involved in lung morphogenesis branching morphogenesis of an epithelial tube respiratory tube development regulation of branching involved in lung morphogenesis lung morphogenesis lung development respiratory system development animal organ morphogenesis regulation of morphogenesis of an epithelium epithelial tube morphogenesis regulation of morphogenesis of a branching structure epithelium development morphogenesis of an epithelium tissue development tissue morphogenesis morphogenesis of a branching structure negative regulation of morphogenesis of an epithelium epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium positive regulation of membrane protein ectodomain proteolysis regulation of proteolysis proteolysis membrane protein proteolysis membrane protein ectodomain proteolysis regulation of membrane protein ectodomain proteolysis positive regulation of proteolysis positive regulation of transcription by RNA polymerase II regulation of endothelial cell apoptotic process humoral immune response phosphatidylinositol 3-kinase/protein kinase B signal transduction vascular endothelial growth factor production positive regulation of interleukin-6 production muscle structure development negative regulation of myoblast differentiation regulation of myoblast differentiation myoblast differentiation regulation of osteoblast differentiation negative regulation of osteoblast differentiation osteoblast differentiation ossification salivary gland development gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis salivary gland morphogenesis exocrine system development bile acid secretion organic anion transport carboxylic acid transport negative regulation of bile acid secretion acid secretion organic acid transport negative regulation of secretion monocarboxylic acid transport regulation of bile acid secretion negative regulation of organic acid transport regulation of organic acid transport positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of transport digestive system development embryo development digestive tract development embryonic organ development embryonic digestive tract development adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of humoral immune response lymphocyte mediated immunity positive regulation of leukocyte mediated immunity regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of B cell mediated immunity humoral immune response mediated by circulating immunoglobulin positive regulation of humoral immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immunoglobulin mediated immune response leukocyte mediated immunity positive regulation of immune effector process positive regulation of adaptive immune response positive regulation of immunoglobulin mediated immune response positive regulation of humoral immune response mediated by circulating immunoglobulin regulation of adaptive immune response immunoglobulin mediated immune response adaptive immune response regulation of B cell mediated immunity regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity B cell mediated immunity regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation vascular associated smooth muscle cell proliferation cellular response to lipopolysaccharide cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to biotic stimulus response to molecule of bacterial origin aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds negative regulation of cellular respiration regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy regulation of cellular respiration regulation of aerobic respiration regulation of oxidative phosphorylation negative regulation of oxidative phosphorylation regulation of signaling receptor activity negative regulation of molecular function negative regulation of signaling receptor activity regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of interleukin-33 production regulation of interleukin-33 production interleukin-33 production response to corticosteroid response to hormone response to steroid hormone response to endogenous stimulus response to glucocorticoid response to alcohol response to ethanol regulation of tube diameter regulation of tube size vascular process in circulatory system blood vessel diameter maintenance vasodilation regulation of anatomical structure size cellular response to stress DNA damage response intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway regulation of hepatocyte proliferation liver morphogenesis epithelial cell proliferation involved in liver morphogenesis hepatocyte proliferation positive regulation of hepatocyte proliferation defense response to virus antiviral innate immune response response to virus epidermis development molting cycle process regulation of hair cycle skin epidermis development hair follicle development hair cycle positive regulation of hair follicle development skin development molting cycle regulation of hair follicle development hair cycle process positive regulation of locomotion positive regulation of cell migration positive regulation of cell motility positive regulation of mononuclear cell migration regulation of mononuclear cell migration regulation of leukocyte migration positive regulation of leukocyte migration mononuclear cell migration regulation of establishment of endothelial barrier endothelium development epithelial cell differentiation regulation of epithelial cell differentiation endothelial cell development regulation of endothelial cell development endothelial cell differentiation regulation of endothelial cell differentiation epithelial cell development establishment of endothelial barrier regulation of DNA biosynthetic process positive regulation of DNA biosynthetic process DNA metabolic process positive regulation of DNA metabolic process DNA biosynthetic process regulation of DNA metabolic process positive regulation of translation post-transcriptional regulation of gene expression translational initiation regulation of translational initiation by iron regulation of translational initiation positive regulation of translational initiation by iron translation regulation of translation positive regulation of translational initiation negative regulation of amyloid-beta clearance amyloid-beta clearance regulation of amyloid-beta clearance synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process branching involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis regulation of animal organ morphogenesis positive regulation of neuroinflammatory response regulation of neuroinflammatory response acute-phase response regulation of heat generation homeostatic process positive regulation of heat generation positive regulation of acute inflammatory response heat generation positive regulation of fever generation acute inflammatory response fever generation multicellular organismal-level homeostasis temperature homeostasis regulation of acute inflammatory response regulation of fever generation defense response to Gram-positive bacterium defense response to bacterium import into cell negative regulation of amino acid transport negative regulation of amine transport carboxylic acid transmembrane transport amino acid transmembrane transport L-amino acid transport L-glutamate import regulation of L-glutamate import across plasma membrane regulation of amino acid transport regulation of amino acid transmembrane transport negative regulation of L-glutamate import across plasma membrane L-glutamate import across plasma membrane organic acid transmembrane transport import across plasma membrane amino acid transport amine transport acidic amino acid transport regulation of amino acid import across plasma membrane dicarboxylic acid transport L-alpha-amino acid transmembrane transport amino acid import across plasma membrane regulation of amine transport L-glutamate transmembrane transport negative regulation of cell cycle negative regulation of mitotic cell cycle regulation of leukocyte differentiation positive regulation of osteoclast differentiation regulation of osteoclast differentiation positive regulation of hemopoiesis regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation	membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle recycling endosome endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle phagocytic cup membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle recycling endosome endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle phagocytic cup cell periphery plasma membrane membrane extracellular region extracellular space cell surface membrane microdomain membrane raft external side of plasma membrane side of membrane somatodendritic compartment cell body neuronal cell body
D, E, F, J, K D, E, F, J, K, L	Tumor necrosis factor receptor superfamily member 1A, membrane form	molecular transducer activity signaling receptor activity transmembrane signaling receptor activity tumor necrosis factor receptor activity death receptor activity protein binding binding cytokine binding tumor necrosis factor binding	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular process cellular response to cytokine stimulus cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular process cellular response to cytokine stimulus signal transduction positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction positive regulation of biological process regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress response to stress positive regulation of defense response inflammatory response regulation of lipid metabolic process primary metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of lipid metabolic process metabolic process regulation of metabolic process lipid metabolic process RNA metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process macromolecule metabolic process negative regulation of extracellular matrix organization regulation of localization regulation of cellular component organization transport negative regulation of biological process extracellular matrix organization negative regulation of transport cellular component organization localization negative regulation of secretion regulation of secretion by cell secretion by cell negative regulation of cellular process negative regulation of secretion by cell cellular component organization or biogenesis regulation of extracellular matrix constituent secretion extracellular structure organization negative regulation of cellular component organization regulation of transport secretion export from cell establishment of localization regulation of secretion negative regulation of extracellular matrix constituent secretion extracellular matrix constituent secretion regulation of extracellular matrix organization external encapsulating structure organization negative regulation of inflammatory response negative regulation of response to stimulus negative regulation of response to external stimulus negative regulation of defense response regulation of amide metabolic process positive regulation of amide metabolic process amide metabolic process prostaglandin metabolic process icosanoid metabolic process fatty acid metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process organic acid metabolic process prostanoid metabolic process small molecule metabolic process monocarboxylic acid metabolic process protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane defense response to bacterium biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external biotic stimulus response to biotic stimulus positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis execution phase of apoptosis apoptotic process programmed cell death developmental process heart development multicellular organismal process heart valve development animal organ development circulatory system development multicellular organism development pulmonary valve development anatomical structure development semi-lunar valve development system development extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway apoptotic signaling pathway cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT cellular response to stress DNA damage response intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus membrane lipid metabolic process regulation of membrane lipid metabolic process regulation of establishment of endothelial barrier cellular developmental process regulation of developmental process endothelium development cell development regulation of cell differentiation epithelial cell differentiation regulation of cell development regulation of epithelial cell differentiation endothelial cell development cell differentiation regulation of endothelial cell development regulation of multicellular organismal process epithelium development regulation of multicellular organismal development endothelial cell differentiation regulation of endothelial cell differentiation tissue development epithelial cell development establishment of endothelial barrier cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor apoptotic process involved in morphogenesis apoptotic process involved in development positive regulation of developmental process positive regulation of apoptotic process involved in morphogenesis positive regulation of apoptotic process involved in development regulation of apoptotic process involved in development anatomical structure morphogenesis regulation of apoptotic process involved in morphogenesis aortic valve development muscle hypertrophy regulation of muscle adaptation system process negative regulation of muscle hypertrophy regulation of system process striated muscle hypertrophy regulation of muscle system process muscle system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy muscle adaptation cardiac muscle hypertrophy negative regulation of multicellular organismal process negative regulation of cardiac muscle hypertrophy regulation of tumor necrosis factor-mediated signaling pathway regulation of cytokine-mediated signaling pathway regulation of response to cytokine stimulus positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription	cellular anatomical structure membrane cell surface cell periphery plasma membrane membrane microdomain membrane raft protein-containing complex receptor complex extracellular region membrane-bounded organelle Golgi membrane intracellular anatomical structure Golgi apparatus cellular anatomical structure membrane cell surface cell periphery plasma membrane membrane microdomain membrane raft protein-containing complex receptor complex extracellular region membrane-bounded organelle Golgi membrane intracellular anatomical structure Golgi apparatus intracellular membrane-bounded organelle endomembrane system intracellular organelle bounding membrane of organelle organelle cytoplasm organelle membrane tumor necrosis factor receptor superfamily complex extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, G, H A, B, C, G, H, I	IPR008983	Tumour necrosis factor-like domain superfamily	Homologous Superfamily
A, B, C, G, H A, B, C, G, H, I	IPR021184	Tumour necrosis factor, conserved site	Conserved Site
A, B, C, G, H A, B, C, G, H, I	IPR006053	Tumour necrosis factor	Family
A, B, C, G, H A, B, C, G, H, I	IPR002959	Tumour necrosis factor alpha	Family
A, B, C, G, H A, B, C, G, H, I	IPR006052	Tumour necrosis factor domain	Domain
D, E, F, J, K D, E, F, J, K, L	IPR033993	Tumor necrosis factor receptor 1A, N-terminal	Domain
D, E, F, J, K D, E, F, J, K, L	IPR052493	Tumor necrosis factor receptor superfamily member 1A	Family
D, E, F, J, K D, E, F, J, K, L	IPR011029	Death-like domain superfamily	Homologous Superfamily
D, E, F, J, K D, E, F, J, K, L	IPR020419	Tumour necrosis factor receptor 1A	Family
D, E, F, J, K D, E, F, J, K, L	IPR000488	Death domain	Domain
D, E, F, J, K D, E, F, J, K, L	IPR001368	TNFR/NGFR cysteine-rich region	Domain
D, E, F, J, K D, E, F, J, K, L	IPR033994	Tumor necrosis factor receptor 1A, death domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, G, H A, B, C, G, H, I	Pharos: P01375	psoriatic arthritis ulcerative colitis Crohn disease hypertensive disorder rheumatoid arthritis malaria pulmonary edema Alzheimer disease asthma hypercalcemia disease leishmaniasis anthracosis hepatic encephalopathy Wilson disease obesity disorder psoriatic arthritis ulcerative colitis Crohn disease hypertensive disorder rheumatoid arthritis malaria pulmonary edema Alzheimer disease asthma hypercalcemia disease leishmaniasis anthracosis hepatic encephalopathy Wilson disease obesity disorder melanoma inflammatory bowel disease transitional cell carcinoma psoriasis glomerulonephritis juvenile idiopathic arthritis status epilepticus hemolytic-uremic syndrome listeriosis polymyositis occupational asthma localized scleroderma dermatomyositis allergic disease sickle cell anemia type 2 diabetes mellitus cardiomyopathy atherosclerosis anemia malignant glioma pneumonia Fanconi anemia liver disease oral submucous fibrosis hereditary hemochromatosis trigeminal neuralgia cancer narcolepsy tubular adenocarcinoma Cardiomegaly granular cell carcinoma drug allergy urinary bladder cancer coronary artery disease bacterial arthritis peripheral neuropathy acute coronary syndrome bipolar disorder mixed glioma venous thromboembolism brain ischemia adenocarcinoma visceral leishmaniasis breast carcinoma chronic beryllium disease thyroid adenoma scleroderma allergic contact dermatitis colitis cardiac arrest pulmonary emphysema colorectal cancer pulmonary hypertension skin disease intrahepatic cholestasis Guillain-Barre syndrome congestive heart failure spindle cell sarcoma neuralgia coronary restenosis malignant colon neoplasm vascular disease refractory anemia placenta disease migraine with or without aura, susceptibility to, 1 pleurisy acute liver failure cutaneous leishmaniasis thrombotic disease postmenopausal osteoporosis chronic kidney disease sarcoma bronchiectasis myocardial stunning chronic obstructive pulmonary disease tuberculosis pulmonary fibrosis gastric ulcer asbestosis HIV wasting syndrome Parkinson disease cardiovirus infectious disease amyotrophic lateral sclerosis type 1 nervous system disorder urticaria hyperhomocysteinemia hypoglycemia cerebrovascular disorder hepatic coma brain edema extrahepatic cholestasis cholestasis retinal disease liver cancer manganese poisoning inborn mitochondrial myopathy muscular atrophy myocardial infarction schizophrenia thyroid gland carcinoma toxic shock syndrome alcoholic liver cirrhosis myocarditis gastric cancer colonic neoplasm lung carcinoma hidradenitis suppurativa glioma pancreatic neoplasm Hodgkins lymphoma diarrheal disease interstitial lung disease congenital diaphragmatic hernia autism spectrum disorder pyoderma gangrenosum juvenile dermatomyositis Hashimoto thyroiditis drug-induced liver injury uveitis heart failure benign connective and soft tissue neoplasm pilocytic astrocytoma vasculitis cervical cancer respiratory system disease linear scleroderma neurodegenerative disease pneumonitis ileocolitis multiple organ dysfunction syndrome rheumatic disorder non-alcoholic fatty liver disease hepatitis B virus infection cutaneous melanoma maturity-onset diabetes of the young adult acute respiratory distress syndrome sarcoidosis arteriosclerosis disorder dementia myocardial ischemia osteoporosis inherited lipid metabolism disorder myopathy lung adenocarcinoma hereditary hyperbilirubinemia desmoid tumor injury gastric neoplasm lung disease arthropathy HIV infectious disease type 1 diabetes mellitus pancreatitis pustulosis palmaris et plantaris lytic metastatic bone lesion autoimmune disease periodontitis urinary bladder neoplasm Behcet disease peritonitis hyperglycemia metabolic syndrome X laryngeal squamous cell carcinoma ankylosing spondylitis cribriform carcinoma Stevens-Johnson syndrome hypotensive disorder acute kidney failure epithelioid sarcoma anxiety disorder Crohn's colitis malignant pancreatic neoplasm bone marrow disease chlamydia infectious disease inborn carbohydrate metabolic disorder vitiligo breast disease infectious meningitis liver neoplasm arthritic joint disease hepatocellular carcinoma Dengue hemorrhagic fever thyroid cancer membranous glomerulonephritis toxic encephalopathy influenza alcoholic hepatitis osteosarcoma hereditary diffuse gastric adenocarcinoma inherited susceptibility to asthma myositis colonic disease lung benign neoplasm alopecia areata colorectal carcinoma interstitial cystitis lymphatic system disease ischemia reperfusion injury squamous cell lung carcinoma major depressive disorder peripheral nervous system disease hyperbilirubinemia kidney disease heart disease COVID-19 benign colon neoplasm migraine disorder encephalitis cribriform carcinoma of breast leukopenia synovitis MALT lymphoma brain injury idiopathic interstitial pneumonia acute myeloid leukemia vertebral column disease cutaneous lupus erythematosus breast cancer SAPHO syndrome fatty liver disease depressive disorder burn prostate disease inherited aplastic anemia
D, E, F, J, K D, E, F, J, K, L	Pharos: P19438	autosomal dominant familial periodic fever primary biliary cholangitis multiple sclerosis cystic fibrosis congestive heart failure autoimmune disease Diabetes Mellitus, Experimental amyloidosis allergic disease type 2 diabetes mellitus brain ischemia pneumonia celiac disease malignant ependymoma colorectal adenoma autosomal dominant familial periodic fever primary biliary cholangitis multiple sclerosis cystic fibrosis congestive heart failure autoimmune disease Diabetes Mellitus, Experimental amyloidosis allergic disease type 2 diabetes mellitus brain ischemia pneumonia celiac disease malignant ependymoma colorectal adenoma medulloblastoma Crohn disease ovarian cancer acquired metabolic disease pilocytic astrocytoma pneumonitis arthritic joint disease heart failure schizophrenia intermittent hydrarthrosis brain injury lung carcinoma malignant pancreatic neoplasm colorectal cancer multiple sclerosis, susceptibility to, 5 pancreatic ductal adenocarcinoma pituitary cancer ankylosing spondylitis glioblastoma astrocytic tumor Behcet disease juvenile idiopathic arthritis cancer maturity-onset diabetes of the young depressive disorder exocrine pancreatic carcinoma periodic fever syndrome hepatocellular carcinoma subependymal giant cell astrocytoma large cell medulloblastoma lung cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.