Annotations: 9EZT

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, D	NAD(P)H dehydrogenase [quinone] 1	oxidoreductase activity NADH:ubiquinone reductase (non-electrogenic) activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NADH dehydrogenase activity cytochrome-b5 reductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor NAD(P)H dehydrogenase (quinone) activity identical protein binding protein binding binding superoxide dismutase activity oxidoreductase activity, acting on superoxide radicals as acceptor oxidoreductase activity NADH:ubiquinone reductase (non-electrogenic) activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NADH dehydrogenase activity cytochrome-b5 reductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor NAD(P)H dehydrogenase (quinone) activity identical protein binding protein binding binding superoxide dismutase activity oxidoreductase activity, acting on superoxide radicals as acceptor antioxidant activity NADPH dehydrogenase activity NADPH dehydrogenase (quinone) activity RNA binding nucleic acid binding	response to stimulus response to stress response to ischemia response to ketone response to lipid response to chemical response to oxygen-containing compound response to testosterone biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to stimulus response to stress response to ischemia response to ketone response to lipid response to chemical response to oxygen-containing compound response to testosterone biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus catabolic process metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process regulation of biological process neuron apoptotic process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process positive regulation of neuron apoptotic process programmed cell death positive regulation of cellular process regulation of neuron apoptotic process cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to metal ion response to toxic substance response to oxidative stress cellular response to stress cellular response to oxidative stress cellular response to chemical stress response to electrical stimulus response to abiotic stimulus protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell redox homeostasis cellular homeostasis homeostatic process negative regulation of biological process negative regulation of protein catabolic process regulation of primary metabolic process negative regulation of cellular process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of macromolecule metabolic process regulation of catabolic process regulation of metabolic process regulation of protein catabolic process response to hydrogen sulfide response to hormone response to endogenous stimulus response to acid chemical response to L-glutamine response to nitrogen compound response to amino acid vitamin E metabolic process fat-soluble vitamin metabolic process small molecule metabolic process vitamin metabolic process detoxification reactive oxygen species metabolic process response to superoxide cellular oxidant detoxification cellular response to oxygen radical cellular response to reactive oxygen species cellular detoxification cellular response to oxygen-containing compound response to reactive oxygen species removal of superoxide radicals superoxide metabolic process cellular response to superoxide cellular response to toxic substance response to oxygen radical negative regulation of programmed cell death negative regulation of apoptotic process ketone metabolic process ubiquinone metabolic process quinone metabolic process negative regulation of ferroptosis regulation of ferroptosis ferroptosis response to alcohol response to ethanol cellular response to hydrogen peroxide response to hydrogen peroxide response to flavonoid cellular response to xenobiotic stimulus xenobiotic metabolic process response to xenobiotic stimulus response to alkaloid response to nutrient levels response to nutrient trans-synaptic signaling signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling synaptic transmission, cholinergic response to lipopolysaccharide response to bacterium response to molecule of bacterial origin vitamin K metabolic process response to amine response to carbohydrate response to estradiol response to tetrachloromethane nitric oxide metabolic process nitric oxide biosynthetic process biosynthetic process reactive nitrogen species metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell body neuronal cell body synapse cell junction cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell body neuronal cell body synapse cell junction membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
C	NAD(P)H dehydrogenase [quinone] 1	oxidoreductase activity NADH:ubiquinone reductase (non-electrogenic) activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NADH dehydrogenase activity cytochrome-b5 reductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor NAD(P)H dehydrogenase (quinone) activity identical protein binding protein binding binding superoxide dismutase activity oxidoreductase activity, acting on superoxide radicals as acceptor oxidoreductase activity NADH:ubiquinone reductase (non-electrogenic) activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NADH dehydrogenase activity cytochrome-b5 reductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor NAD(P)H dehydrogenase (quinone) activity identical protein binding protein binding binding superoxide dismutase activity oxidoreductase activity, acting on superoxide radicals as acceptor antioxidant activity NADPH dehydrogenase activity NADPH dehydrogenase (quinone) activity RNA binding nucleic acid binding	response to stimulus response to stress response to ischemia response to ketone response to lipid response to chemical response to oxygen-containing compound response to testosterone biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to stimulus response to stress response to ischemia response to ketone response to lipid response to chemical response to oxygen-containing compound response to testosterone biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus catabolic process metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process regulation of biological process neuron apoptotic process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process positive regulation of neuron apoptotic process programmed cell death positive regulation of cellular process regulation of neuron apoptotic process cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to metal ion response to toxic substance response to oxidative stress cellular response to stress cellular response to oxidative stress cellular response to chemical stress response to electrical stimulus response to abiotic stimulus protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cell redox homeostasis cellular homeostasis homeostatic process negative regulation of biological process negative regulation of protein catabolic process regulation of primary metabolic process negative regulation of cellular process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of macromolecule metabolic process regulation of catabolic process regulation of metabolic process regulation of protein catabolic process response to hydrogen sulfide response to hormone response to endogenous stimulus response to acid chemical response to L-glutamine response to nitrogen compound response to amino acid vitamin E metabolic process fat-soluble vitamin metabolic process small molecule metabolic process vitamin metabolic process detoxification reactive oxygen species metabolic process response to superoxide cellular oxidant detoxification cellular response to oxygen radical cellular response to reactive oxygen species cellular detoxification cellular response to oxygen-containing compound response to reactive oxygen species removal of superoxide radicals superoxide metabolic process cellular response to superoxide cellular response to toxic substance response to oxygen radical negative regulation of programmed cell death negative regulation of apoptotic process ketone metabolic process ubiquinone metabolic process quinone metabolic process negative regulation of ferroptosis regulation of ferroptosis ferroptosis response to alcohol response to ethanol cellular response to hydrogen peroxide response to hydrogen peroxide response to flavonoid cellular response to xenobiotic stimulus xenobiotic metabolic process response to xenobiotic stimulus response to alkaloid response to nutrient levels response to nutrient trans-synaptic signaling signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling synaptic transmission, cholinergic response to lipopolysaccharide response to bacterium response to molecule of bacterial origin vitamin K metabolic process response to amine response to carbohydrate response to estradiol response to tetrachloromethane nitric oxide metabolic process nitric oxide biosynthetic process biosynthetic process reactive nitrogen species metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell body neuronal cell body synapse cell junction cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell body neuronal cell body synapse cell junction membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, D	IPR003680	Flavodoxin-like fold	Domain
A, B, D	IPR029039	Flavoprotein-like superfamily	Homologous Superfamily
A, B, D	IPR051545	NAD(P)H dehydrogenase (quinone)	Family
C	IPR003680	Flavodoxin-like fold	Domain
C	IPR029039	Flavoprotein-like superfamily	Homologous Superfamily
C	IPR051545	NAD(P)H dehydrogenase (quinone)	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, D	Pharos: P15559	non-small cell lung carcinoma hemolytic-uremic syndrome spinocerebellar ataxia type 17 cancer plasma cell myeloma myeloid leukemia contact dermatitis papilloma liver disease chronic monocytic leukemia urinary bladder cancer Neoplasms, Experimental obesity disorder breast cancer squamous papilloma non-small cell lung carcinoma hemolytic-uremic syndrome spinocerebellar ataxia type 17 cancer plasma cell myeloma myeloid leukemia contact dermatitis papilloma liver disease chronic monocytic leukemia urinary bladder cancer Neoplasms, Experimental obesity disorder breast cancer squamous papilloma hyperglycemia kidney disease Parkinson disease asthma prostate cancer breast carcinoma cholestasis colorectal cancer diabetes mellitus osteoarthritis pancreatic intraductal papillary-mucinous carcinoma acute kidney failure plantar fibromatosis alcohol withdrawal astrocytic tumor lung cancer benign neoplasm subependymal giant cell astrocytoma myopathy colorectal carcinoma endometriosis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma papillomatosis large cell medulloblastoma attention deficit hyperactivity disorder, inattentive type psoriasis childhood acute lymphoblastic leukemia chronic obstructive pulmonary disease nasopharyngeal carcinoma urinary bladder neoplasm cutaneous lupus erythematosus diastrophic dysplasia head and neck cancer pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell neoplasm lung adenocarcinoma atypical teratoid rhabdoid tumor malignant pancreatic neoplasm schizophrenia medulloblastoma myeloid neoplasm toxic encephalopathy
C	Pharos: P15559	non-small cell lung carcinoma hemolytic-uremic syndrome spinocerebellar ataxia type 17 cancer plasma cell myeloma myeloid leukemia contact dermatitis papilloma liver disease chronic monocytic leukemia urinary bladder cancer Neoplasms, Experimental obesity disorder breast cancer squamous papilloma non-small cell lung carcinoma hemolytic-uremic syndrome spinocerebellar ataxia type 17 cancer plasma cell myeloma myeloid leukemia contact dermatitis papilloma liver disease chronic monocytic leukemia urinary bladder cancer Neoplasms, Experimental obesity disorder breast cancer squamous papilloma hyperglycemia kidney disease Parkinson disease asthma prostate cancer breast carcinoma cholestasis colorectal cancer diabetes mellitus osteoarthritis pancreatic intraductal papillary-mucinous carcinoma acute kidney failure plantar fibromatosis alcohol withdrawal astrocytic tumor lung cancer benign neoplasm subependymal giant cell astrocytoma myopathy colorectal carcinoma endometriosis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma papillomatosis large cell medulloblastoma attention deficit hyperactivity disorder, inattentive type psoriasis childhood acute lymphoblastic leukemia chronic obstructive pulmonary disease nasopharyngeal carcinoma urinary bladder neoplasm cutaneous lupus erythematosus diastrophic dysplasia head and neck cancer pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell neoplasm lung adenocarcinoma atypical teratoid rhabdoid tumor malignant pancreatic neoplasm schizophrenia medulloblastoma myeloid neoplasm toxic encephalopathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.