9IIR | pdb_00009iir

human alpha 7 nicotinic acetylcholine receptor in complex with GAT107 and calcium (desensitized state)

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Neuronal acetylcholine receptor subunit alpha-7	amide binding amyloid-beta binding binding peptide binding neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity signaling receptor activity transmembrane signaling receptor activity acetylcholine receptor activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity amide binding amyloid-beta binding binding peptide binding neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity signaling receptor activity transmembrane signaling receptor activity acetylcholine receptor activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity toxic substance binding monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity channel regulator activity ion channel regulator activity inorganic molecular entity transmembrane transporter activity molecular function regulator activity monoatomic anion channel activity transporter regulator activity inorganic anion transmembrane transporter activity chloride channel regulator activity chloride channel activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic cation channel activity calcium ion transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity cation binding acetylcholine binding ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity transmitter-gated monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ligand-gated channel activity acetylcholine-gated monoatomic cation-selective channel activity ligand-gated monoatomic cation channel activity gated channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential transmitter-gated channel activity	cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling modulation of chemical synaptic transmission regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication synaptic signaling modulation of excitatory postsynaptic potential cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling modulation of chemical synaptic transmission regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of cell communication positive regulation of signal transduction positive regulation of excitatory postsynaptic potential positive regulation of biological process positive regulation of response to stimulus positive regulation of cellular process positive regulation of signaling regulation of tumor necrosis factor production negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process tumor necrosis factor superfamily cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process localization transport monoatomic ion transport establishment of localization positive regulation of molecular function regulation of molecular function positive regulation of transferase activity regulation of catalytic activity positive regulation of CoA-transferase activity positive regulation of catalytic activity regulation of transferase activity amyloid precursor protein catabolic process regulation of protein metabolic process regulation of amyloid precursor protein catabolic process primary metabolic process regulation of primary metabolic process protein metabolic process amyloid precursor protein metabolic process cognition behavior learning or memory memory inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis cellular component organization cell junction organization dendritic spine organization postsynapse organization plasma membrane bounded cell projection organization cell projection organization neuron projection organization synapse organization cellular component organization or biogenesis regulation of amide metabolic process regulation of amyloid-beta formation negative regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process amide metabolic process negative regulation of protein metabolic process amyloid-beta formation negative regulation of amyloid-beta formation negative regulation of amide metabolic process response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus regulation of cellular component organization regulation of amyloid fibril formation amyloid fibril formation regulation of supramolecular fiber organization supramolecular fiber organization cellular response to nitrogen compound cellular response to acetylcholine response to oxygen-containing compound response to nitrogen compound acetylcholine receptor signaling pathway postsynaptic signal transduction cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to acetylcholine cellular developmental process plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation anatomical structure development system development developmental process dendrite arborization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection arborization neuron development positive regulation of protein metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process intracellular signal transduction positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade long-term synaptic potentiation positive regulation of long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of long-term synaptic potentiation transmembrane transport monoatomic ion transmembrane transport cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation response to amyloid-beta sensory perception sensory processing positive regulation of amyloid-beta formation positive regulation of amide metabolic process positive regulation of amyloid precursor protein catabolic process short-term memory regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation monoatomic cation transport calcium ion transport metal ion transport response to nicotine	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell projection neuron projection plasma membrane bounded cell projection protein-containing complex cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell projection neuron projection plasma membrane bounded cell projection protein-containing complex plasma membrane protein complex membrane protein complex transporter complex receptor complex acetylcholine-gated channel complex transmembrane transporter complex plasma membrane signaling receptor complex monoatomic ion channel complex membrane microdomain membrane raft plasma membrane raft

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR002394	Nicotinic acetylcholine receptor	Family
A, B, C, D, E	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A, B, C, D, E	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A, B, C, D, E	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, B, C, D, E	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A, B, C, D, E	IPR006201	Neurotransmitter-gated ion-channel	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E	Pharos: P36544	chromosome 15q13.3 microdeletion syndrome Alzheimer disease Sudden infant death syndrome nicotine dependence spina bifida cystica auditory perceptual disorders substance withdrawal syndrome visual epilepsy omphalocele schizophrenia onchocerciasis lung benign neoplasm bipolar disorder brain injury myelomeningocele chromosome 15q13.3 microdeletion syndrome Alzheimer disease Sudden infant death syndrome nicotine dependence spina bifida cystica auditory perceptual disorders substance withdrawal syndrome visual epilepsy omphalocele schizophrenia onchocerciasis lung benign neoplasm bipolar disorder brain injury myelomeningocele epilepsy, idiopathic generalized autism glaucoma strongyloidiasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.