9L7E | pdb_00009l7e

Crystal structure of human kinesin-1 motor domain (G234A mutant) in complex with ADP

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Kinesin-1 heavy chain	microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding protein binding tubulin binding cell adhesion molecule binding cadherin binding protein-containing complex binding identical protein binding plus-end-directed microtubule motor activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	protein localization establishment of protein localization cellular localization nitrogen compound transport protein localization to synapse transport protein transport along microtubule microtubule-based protein transport localization cellular macromolecule localization establishment of localization in cell transport along microtubule anterograde axonal transport axo-dendritic protein transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein localization to synapse transport protein transport along microtubule microtubule-based protein transport localization cellular macromolecule localization establishment of localization in cell transport along microtubule anterograde axonal transport axo-dendritic protein transport anterograde axonal protein transport intracellular transport axonal transport establishment of localization protein localization to presynapse axo-dendritic transport protein transport macromolecule localization microtubule-based transport cellular process microtubule-based process cytoskeleton-dependent intracellular transport microtubule-based movement protein localization to cell junction intracellular protein transport centrosome localization microtubule organizing center localization positive regulation of protein localization to plasma membrane regulation of localization regulation of cellular process regulation of protein localization positive regulation of biological process regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation positive regulation of protein localization to membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of cellular localization positive regulation of protein localization regulation of protein localization to plasma membrane vesicle localization establishment of organelle localization establishment of vesicle localization organelle localization synaptic vesicle localization synaptic vesicle transport regulation of potassium ion transport regulation of transport regulation of monoatomic ion transport metal ion transport positive regulation of potassium ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport potassium ion transport monoatomic cation transport regulation of metal ion transport vesicle cytoskeletal trafficking organelle transport along microtubule dense core granule cytoskeletal transport retrograde neuronal dense core vesicle transport vesicle transport along microtubule dense core granule localization secretory granule localization dense core granule transport retrograde axonal transport cytosolic transport regulation of biological quality regulation of membrane potential anterograde neuronal dense core vesicle transport cellular component disassembly protein-containing complex organization protein-containing complex disassembly protein-RNA complex disassembly cellular component organization organelle organization protein-RNA complex organization organelle disassembly cellular component organization or biogenesis stress granule disassembly plus-end-directed organelle transport along microtubule plus-end-directed vesicle transport along microtubule lysosome localization vacuolar localization positive regulation of cell communication signaling modulation of chemical synaptic transmission positive regulation of synaptic transmission, GABAergic cell communication synaptic signaling trans-synaptic signaling regulation of signaling synaptic transmission, GABAergic positive regulation of synaptic transmission cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication positive regulation of signaling regulation of synaptic transmission, GABAergic mitochondrion distribution mitocytosis establishment of mitochondrion localization export from cell mitochondrion localization migracytosis lymphocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus leukocyte mediated cytotoxicity response to biotic stimulus immune effector process immune system process defense response to other organism response to stress natural killer cell mediated cytotoxicity innate immune response leukocyte mediated immunity response to external biotic stimulus natural killer cell mediated immunity cell killing regulation of cellular component organization regulation of modification of synaptic structure regulation of synapse structure or activity synapse organization modification of synaptic structure regulation of modification of synapse structure, modulating synaptic transmission regulation of synapse organization cell junction organization response to type II interferon response to cytokine cellular response to type II interferon response to peptide response to chemical cellular response to cytokine stimulus multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development cytoplasm organization anterograde dendritic transport dendritic transport anterograde dendritic transport of neurotransmitter receptor complex protein-containing complex localization receptor localization to synapse establishment of mitochondrion localization, microtubule-mediated mitochondrion transport along microtubule	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol protein-containing complex intracellular membraneless organelle intracellular organelle cytoskeleton organelle membraneless organelle microtubule associated complex kinesin complex microtubule cytoskeleton cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol protein-containing complex intracellular membraneless organelle intracellular organelle cytoskeleton organelle membraneless organelle microtubule associated complex kinesin complex microtubule cytoskeleton membrane-bounded organelle vacuolar membrane lytic vacuole cytolytic granule vacuole intracellular membrane-bounded organelle lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane cytolytic granule membrane lysosome ciliary rootlet cilium plasma membrane bounded cell projection cell projection perinuclear region of cytoplasm polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm mitochondrion vesicle centrosome microtubule organizing center centriolar satellite intracellular vesicle phagocytic vesicle cytoplasmic vesicle endocytic vesicle dendrite cytoplasm somatodendritic compartment dendrite dendritic tree cytosolic region postsynapse synapse cell junction postsynaptic cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001752	Kinesin motor domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR019821	Kinesin motor domain, conserved site	Conserved Site
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR027640	Kinesin-like protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P33176	non-small cell lung carcinoma diabetes mellitus astrocytic tumor dermatomyositis glioblastoma pancreatic ductal adenocarcinoma progressive supranuclear palsy atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma psoriasis cutaneous lupus erythematosus Down syndrome medulloblastoma non-small cell lung carcinoma diabetes mellitus astrocytic tumor dermatomyositis glioblastoma pancreatic ductal adenocarcinoma progressive supranuclear palsy atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma psoriasis cutaneous lupus erythematosus Down syndrome medulloblastoma ovarian cancer primitive neuroectodermal tumor ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.