9MS2 | pdb_00009ms2

Crystal structure of human CYP3A5 in complex with SJYHJ-111

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Cytochrome P450 3A5	oxidoreductase activity catalytic activity estrogen 16-alpha-hydroxylase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen steroid hydroxylase activity oxygen binding binding small molecule binding estrogen 2-hydroxylase activity retinoic acid 4-hydroxylase activity testosterone 6-beta-hydroxylase activity tetrapyrrole binding oxidoreductase activity catalytic activity estrogen 16-alpha-hydroxylase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen steroid hydroxylase activity oxygen binding binding small molecule binding estrogen 2-hydroxylase activity retinoic acid 4-hydroxylase activity testosterone 6-beta-hydroxylase activity tetrapyrrole binding heme binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding	oxidative demethylation demethylation metabolic process cellular process lipid modification primary metabolic process lipid hydroxylation lipid metabolic process diterpenoid metabolic process oxoacid metabolic process regulation of hormone levels biological regulation carboxylic acid metabolic process organic acid metabolic process oxidative demethylation demethylation metabolic process cellular process lipid modification primary metabolic process lipid hydroxylation lipid metabolic process diterpenoid metabolic process oxoacid metabolic process regulation of hormone levels biological regulation carboxylic acid metabolic process organic acid metabolic process hormone metabolic process retinoic acid metabolic process retinoid metabolic process small molecule metabolic process regulation of biological quality monocarboxylic acid metabolic process terpenoid metabolic process isoprenoid metabolic process aflatoxin metabolic process mycotoxin metabolic process toxin metabolic process secondary metabolic process catabolic process alkaloid catabolic process alkaloid metabolic process estrogen metabolic process steroid metabolic process cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus xenobiotic metabolic process response to xenobiotic stimulus xenobiotic catabolic process alcohol metabolic process olefinic compound metabolic process retinol metabolic process primary alcohol metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle intracellular membrane-bounded organelle organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle intracellular membrane-bounded organelle organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008072	Cytochrome P450, E-class, CYP3A	Family
A, B	IPR002402	Cytochrome P450, E-class, group II	Family
A, B	IPR017972	Cytochrome P450, conserved site	Conserved Site
A, B	IPR050705	Cytochrome P450 3A	Family
A, B	IPR001128	Cytochrome P450	Family
A, B	IPR036396	Cytochrome P450 superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P20815	prostate cancer kidney disease essential hypertension ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer psoriasis atypical teratoid rhabdoid tumor Thrombosis essential hypertension, genetic interstitial cystitis lung adenocarcinoma malignant glioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia prostate cancer kidney disease essential hypertension ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer psoriasis atypical teratoid rhabdoid tumor Thrombosis essential hypertension, genetic interstitial cystitis lung adenocarcinoma malignant glioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia schizophrenia Barrett esophagus thrombotic disease esophageal adenocarcinoma toxic encephalopathy glioblastoma lung cancer malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma periodontitis cutaneous lupus erythematosus HIV infectious disease large cell medulloblastoma lung carcinoma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.