Annotations: 9QWO

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E [auth C], F [auth D]	Isoform 1 of Vinculin	protein binding binding alpha-catenin binding cell adhesion molecule binding cadherin binding molecular adaptor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding dystroglycan binding cytoskeletal protein binding actin binding structural molecule activity beta-catenin binding	regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion biological regulation cell-substrate adhesion regulation of cellular component biogenesis regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization cellular process regulation of focal adhesion assembly regulation of cell-substrate junction assembly cell-cell adhesion epithelial cell-cell adhesion lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly lamellipodium organization cell projection assembly developmental process tissue morphogenesis anatomical structure morphogenesis epithelium development anatomical structure development morphogenesis of an epithelium tissue development multicellular organismal process regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation response to stress coagulation regulation of biological quality response to wounding platelet activation apical junction assembly cell-cell junction assembly cell-cell junction organization negative regulation of locomotion regulation of cell motility negative regulation of biological process regulation of locomotion negative regulation of cellular process regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion axon extension axonogenesis cellular developmental process developmental growth plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation system development neuron projection extension developmental cell growth growth nervous system development axon development cell morphogenesis involved in neuron differentiation developmental growth involved in morphogenesis generation of neurons neuron development adherens junction organization adherens junction assembly protein localization localization cellular localization protein localization to cell surface cellular macromolecule localization macromolecule localization regulation of localization regulation of protein localization regulation of protein localization to cell-cell junction regulation of protein localization to adherens junction protein localization to adherens junction protein localization to cell-cell junction regulation of cellular localization protein localization to cell junction regulation of establishment of endothelial barrier regulation of developmental process endothelium development regulation of cell differentiation epithelial cell differentiation regulation of cell development regulation of epithelial cell differentiation endothelial cell development regulation of endothelial cell development regulation of multicellular organismal process regulation of multicellular organismal development endothelial cell differentiation regulation of endothelial cell differentiation epithelial cell development establishment of endothelial barrier maintenance of blood-brain barrier multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis	intracellular anatomical structure cell cortex cortical cytoskeleton intracellular membraneless organelle actin cytoskeleton intracellular organelle cell periphery cellular anatomical structure cytoskeleton organelle membraneless organelle cortical actin cytoskeleton terminal web cytoplasm intracellular anatomical structure cell cortex cortical cytoskeleton intracellular membraneless organelle actin cytoskeleton intracellular organelle cell periphery cellular anatomical structure cytoskeleton organelle membraneless organelle cortical actin cytoskeleton terminal web cytoplasm cell-cell junction anchoring junction cell junction extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol sarcolemma plasma membrane membrane costamere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex cluster of actin-based cell projections brush border adherens junction intercalated disc fascia adherens cell-cell contact zone cell-substrate junction desmosome inner dense plaque of desmosome vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen cytoplasmic vesicle organelle lumen specific granule lumen secretory granule secretory vesicle specific granule podosome podosome ring focal adhesion outer dense plaque of desmosome membrane microdomain membrane raft apical junction complex zonula adherens ficolin-1-rich granule ficolin-1-rich granule lumen protein-containing complex cell projection
C [auth E], G [auth F]	Isoform Gamma of Paxillin	cytoskeletal protein binding protein binding binding vinculin binding protein phosphatase binding phosphatase binding enzyme binding signaling receptor binding neuropilin binding beta-catenin binding cation binding ion binding metal ion binding small molecule binding	endothelial cell migration cell migration cellular process cell motility cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction endothelial cell migration cell migration cellular process cell motility cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication cellular response to nitrogen compound response to peptide hormone cellular response to growth hormone stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus growth hormone receptor signaling pathway cell surface receptor signaling pathway response to endogenous stimulus cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to growth hormone cellular response to chemical stimulus response to chemical cellular response to oxidative stress cellular response to chemical stress response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress cellular response to stress response to stress regulation of signaling protein-containing complex organization regulation of signal transduction cellular component organization cellular component biogenesis signal complex assembly cellular component assembly regulation of response to stimulus protein-containing complex assembly regulation of cell communication cellular component organization or biogenesis positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process positive regulation of cellular component organization positive regulation of biological process regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly actin filament-based process stress fiber assembly positive regulation of cellular process regulation of actin filament organization actin cytoskeleton organization actomyosin structure organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization actin filament organization regulation of cellular component biogenesis positive regulation of supramolecular fiber organization regulation of organelle organization regulation of stress fiber assembly organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization regulation of actin cytoskeleton organization actin filament bundle assembly regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery cell cortex intracellular anatomical structure cytoplasm cell-cell junction cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery cell cortex intracellular anatomical structure cytoplasm cell-cell junction cytosol plasma membrane membrane actin filament bundle intracellular membraneless organelle actin cytoskeleton actomyosin intracellular organelle cytoskeleton organelle membraneless organelle stress fiber contractile actin filament bundle protein-containing complex microtubule associated complex microtubule cytoskeleton
D [auth G], H	Paxillin	cation binding ion binding binding metal ion binding small molecule binding	cell adhesion cellular process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol anchoring junction cell junction focal adhesion cell-substrate junction cell periphery cell cortex intracellular organelle cytoskeleton organelle membraneless organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol anchoring junction cell junction focal adhesion cell-substrate junction cell periphery cell cortex intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E [auth C], F [auth D]	IPR017997	Vinculin	Family
A, B, E [auth C], F [auth D]	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A, B, E [auth C], F [auth D]	IPR006077	Vinculin/alpha-catenin	Family
A, B, E [auth C], F [auth D]	IPR000633	Vinculin, conserved site	Conserved Site
C [auth E], G [auth F]	IPR001904	Paxillin, Lim domain 4	Domain
C [auth E], G [auth F]	IPR047072	Paxillin, Lim domain 2	Domain
C [auth E], G [auth F]	IPR001781	Zinc finger, LIM-type	Domain
C [auth E], G [auth F]	IPR047075	Paxillin/TGFB1I1, LIM domain 1	Domain
D [auth G], H	IPR047075	Paxillin/TGFB1I1, LIM domain 1	Domain
D [auth G], H	IPR001904	Paxillin, Lim domain 4	Domain
D [auth G], H	IPR047072	Paxillin, Lim domain 2	Domain
D [auth G], H	IPR001781	Zinc finger, LIM-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, E [auth C], F [auth D]	Pharos: P18206	dilated cardiomyopathy 1W hypertrophic cardiomyopathy 15 dilated cardiomyopathy osteoporosis acute coronary syndrome cardiomyopathy hypertrophic cardiomyopathy malignant ependymoma ovarian cancer spondyloarthropathy Crohn disease familial isolated dilated cardiomyopathy lung carcinoma malignant pancreatic neoplasm Osteoporosis, Age-Related dilated cardiomyopathy 1W hypertrophic cardiomyopathy 15 dilated cardiomyopathy osteoporosis acute coronary syndrome cardiomyopathy hypertrophic cardiomyopathy malignant ependymoma ovarian cancer spondyloarthropathy Crohn disease familial isolated dilated cardiomyopathy lung carcinoma malignant pancreatic neoplasm Osteoporosis, Age-Related pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma astrocytic tumor Charcot-Marie-Tooth disease diabetes mellitus familial dilated cardiomyopathy glioblastoma inflammatory bowel disease malignant colon neoplasm medulloblastoma tuberculosis atypical teratoid rhabdoid tumor familial hypertrophic cardiomyopathy lung cancer
C [auth E], G [auth F]	Pharos: P49023	non-small cell lung carcinoma Neoplasm Metastasis attention deficit hyperactivity disorder, inattentive type glioblastoma cancer malignant ependymoma osteosarcoma malignant glioma polycystic ovary syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.